1400 years ago people used iron which always rusted. Rust is oxidation of iron, but at that time nobody knew that oxidation can affect your heart.
Today we know that there are two types of cholesterol, one is good and the other is bad. Bad cholesterol is actually oxidized.
What is oxidized cholesterol?
The cholesterol that dangerously builds up on artery walls is oxidized. Oxidation is very damaging to the cholesterol cells. Oxidation is the result of a normal body process, but if something triggers an overproduction of oxidized cholesterol, it can be dangerous. Your immune system may mistake oxidized cholesterol for bacteria. Your immune system then tries to fight it off, which can cause inflammation inside of the arterial wall. This can lead to atherosclerosis or heart disease.
Oxidized cholesterol clogs the arteries and causes heart disease. This was known recently, however this was portrayed in the Quran 1400 years before it was discovered.
"Ran رَانَ" means rust. Their hearts have something oxidized.
"Locks upon their hearts" means something is blocking access to their hearts. Those people back then used locks made of iron which rusted (oxidized iron). Their hearts are clogged by something oxidized. Today we know that oxidized cholesterol clogs arteries.
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