The skin burning sensation is carried to the brain by nerves.
However if the nerve endings at outer skin is damaged no signals would be carried to the brain, hence no burning sensation is felt. This was known recently, however this was portrayed in the Quran 1400 years before it was discovered. The Quran says that those who will burn in hell their skins will be replaced with new ones every time it is roasted so that they may feel the pain:
Those who disbelieve in Our verses, We will drive them into a fire, every time their skins are roasted We will replace their skins with other new skins so that they may taste the torture. Allah is ever Exalted in Might and Wise.
٥٦ إِنَّ الَّذِينَ كَفَرُوا بِآيَاتِنَا سَوْفَ نُصْلِيهِمْ نَارًا كُلَّمَا نَضِجَتْ جُلُودُهُمْ بَدَّلْنَاهُمْ جُلُودًا غَيْرَهَا لِيَذُوقُوا الْعَذَابَ ۗ إِنَّ اللَّهَ كَانَ عَزِيزًا حَكِيمًا
"Every time their skins are roasted We will replace their skins with other new skins so that they may taste the torture" today we know why, because once the nerves are damaged they don't transmit the pain anymore.
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